Retinoblastoma and the Genetic Theory of Cancer: An Old Paradigm Trying to Survive to the Evidence

Figure 1

The distribution of retinoblastoma by laterality in a sample of 387 patients referred to the Ocular Oncology Unit of the Department of Ophthalmology of the University of Siena (Italy). Five cases, diagnosed beyond the age of 87 months, are not reported in the diagram. As it can be appreciated, the distribution of unilateral Rb by age at diagnosis is highly skewed, and therefore, the calculation of the “mean” in this sample may lead to unreliable inferences.