Impact of Histopathological Diagnosis with Ancillary Immunohistochemical Studies on Lung Cancer Subtypes Incidence and Survival: A Population-Based Study
Table 1
Main clinical-pathological characteristics of lung cancer histotypes: Ticino (southern Switzerland), 1996–2010.
Variable
All cases (100%)
AC (40.4%)
LCC/NSCLC (21.2%)
SmCC (15.3%)
SqCC (23.1%)
value
Age (yrs)
<0.0001
median
68.0
67.0
68.0
68.0
69.0
0.0022
range
26–94
26–94
34–93
40–94
38–93
Age-specific groups, (%)
<50
150 (6.1%)
83 (8.3%)
31 (5.9%)
21 (5.6%)
15 (2.6%)
<0.0001
50–59
395 (16.0%)
176 (17.7%)
87 (16.7%)
55 (14.5%)
77 (13.5%)
60–69
841 (34.1%)
336 (33.7%)
173 (33.1%)
133 (35.2%)
199 (34.9%)
70–79
813 (32.9%)
308 (30.9%)
169 (32.4%)
227 (33.6%)
209 (36.7%)
≥80
268 (10.9%)
94 (9.4%)
62 (11.9%)
42 (11.1%)
70 (12.3%)
Sex, (%)
women
759 (30.8%)
373 (37.4%)
169 (32.4%)
106 (28.0%)
111 (19.5%)
<0.0001
men
1708 (69.2%)
624 (62.6%)
353 (67.6%)
272 (72.0%)
459 (80.5%)
Histological grade, (%)
well differentiated
70 (3.8%)
52 (7.4%)
0 (0%)
NA
14 (3.1%)
<0.0001*
moderately differentiated
408 (22.1%)
211 (30.0%)
0 (0%)
192 (42.7%)
poorly differentiated
1365 (74.1%)
440 (62.6%)
522 (100%)
244 (54.2%)
unknown
624
294
120
Tumour extent at diagnosis
limited disease (M0)
1491 (60.4%)
600 (60.2%)
273 (52.3%)
178 (47.1%)
440 (77.2%)
<0.0001
extensive disease (M1)
976 (39.6%)
397 (39.8%)
249 (47.7%)
200 (52.9%)
130 (22.8%)
Period of diagnosis
1996–2003
1214 (49.2%)
408 (40.9%)
334 (64.0%)
197 (52.1%)
275 (48.3%)
<0.0001
2004–2010
1253 (50.8%)
589 (59.1%)
188 (36.0%)
181 (47.9%)
295 (51.7%)
AC: adenocarcinoma; LLC/NSCLC: large cell carcinoma/non-small-cell lung cancer; SmCC: small cell carcinoma; SqCC: squamous cell carcinoma; NA: not applicable
*The comparison was performed only between AC and SqCC; histological grade is not applicable for SmCC.
