Risk of Late Mortality and Second Malignant Neoplasms among 5-Year Survivors of Young Adult Cancer: A Report of the Childhood, Adolescent, and Young Adult Cancer Survivors Research Program

Table 4

Hazard ratio of mortality for all causes of death.

	All causes of death (𝑁=138)
	Unadjusted HR (95% CI)	Adjusted HR (95% CI)
Sex^a
Female	1	1
Male	1.9 (1.4–2.7)*	1.7 (1.2–2.4)*
Type of original cancer^b
Lymphoma	1	1
Central nervous system tumors	3.1 (1.9–5.2)*	3.4 (2.1–5.7)*
Soft tissue sarcomas	1.1 (0.6–2.2)	1.2 (0.6–2.3)
Germ cell tumor	0.3 (0.2–0.7)*	0.4 (0.2–0.7)*
Melanoma	0.5 (0.3–0.9)*	0.7 (0.4–1.2)
Carcinoma (except of skin)	0.4 (0.2–0.6)*	0.5 (0.3–0.8)*
Others^c	1.0 (0.5–1.9)	1.1 (0.6–2.1)
Diagnosis period^d
1970–1979	1	1
1980–1989	0.7 (0.4–1.0)	0.6 (0.4–0.9)*
1990–1995	0.9 (0.5–1.5)	0.9 (0.5–1.4)
Relapse < 5 years after diagnosis^e
No	1	1
Yes	4.1 (2.7–6.3)*	2.9 (1.9–4.5)*
Having chemotherapy^f
No	1	1
Yes	1.1 (0.8–1.6)	0.9 (0.6–1.5)
Having radiation^f
No	1	1
Yes	2.7 (2–3.8)*	2.0 (1.3–3.1)*
Having surgery^f
No	1	1
Yes	0.6 (0.5–0.9)*	1.3 (0.9–1.9)

^∗𝑃<0.05.
^aMultivariate analyses adjusted for type of original cancer, diagnosis period, and relapse < 5 years after diagnosis.
^bMultivariate analyses adjusted for sex, diagnosis period, and relapse < 5 years after diagnosis.
^cOther types of original cancers include leukemia, bone tumor, and miscellaneous-specified tumor.
^dMultivariate analyses adjusted for sex, type of original cancer, and relapse < 5 years after diagnosis.
^eMultivariate analyses adjusted for sex, type of original cancer, and diagnosis period.
^fMultivariate analyses adjusted for sex, type of original cancer, diagnosis period, and relapse < 5 years after diagnosis.