Predictors of Immunosuppressive Regulatory T Lymphocytes in Healthy Women

Table 2

Linear regression analyses of epidemiological predictors of regulatory T-cell (Treg) levels among 75 healthy women at Roswell Park Cancer Institute, Buffalo, NY, USA, 2008-2009.

Variable	β	𝑃 value	𝑅^2
Demographic variables
^1Age (years)	0.02	0.05	0.05
^2Education	−0.97	0.005	0.10
^1BMI (kg/mm^2)	0.01	0.78	0.001
BMI (kg/mm^2)
18–24	Reference
25–29	1.11	0.004	0.12
30 or more	0.22	0.52
Lifestyle factors
Smoking	0.71	0.02	0.07
^3Alcohol intake	0.01	0.19	0.02
Exercise
None	Reference		0.09
1-2 days/week	−0.22	0.55
3 or more days/week	−0.94	0.01
Reproductive factors
Menopausal status	0.63	0.04	0.05
^4Age at first birth	−0.78	0.01	0.10
^5Age at menarche	−0.41	0.26	0.02
Oral contraceptives	−0.70	0.03	0.06
HRT	0.84	0.02	0.07
Parity	−0.35	0.39	0.01
Breast feeding	−0.50	0.10	0.04
Family history	0.32	0.46	0.01
Medications
^6Multivitamins	−0.25	0.52	0.01
^7Ibuprofen	−0.82	0.01	0.08
^7Osteoporosis medication	1.18	0.003	0.11
^7Acetaminophen	−0.54	0.19	0.02
^7Aspirin	0.58	0.11	0.03
^7Prednisone	−0.27	0.49	0.01
^8Diet
Vegetable	−0.02	0.19	0.02
Fruits	−0.02	0.28	0.02

HRT: hormone replacement therapy.
¹Continuous variable.
²Education level categorized as less than or equal to high school and more than high school.
³Frequency of drinking beer/wine/liquor per month in the past one year.
⁴Age at first birth categorized as ≤24 years (reference) and >24 years.
⁵Age at menarche categorized as ≤13 years and ≥14 years.
⁶Current intake of multivitamins categorized as none = 0 and 1 = yes.
⁷Intake in the past: 0 = Never, 1 = yes, occasionally or at least once a week for one full year.
⁸Frequency per week.
Exercise was defined as days per week of at least 20 min of exercise currently.