The Interaction between Pesticide Use and Genetic Variants Involved in Lipid Metabolism on Prostate Cancer Risk

Table 2

Associations between intensity-weighted lifetime days of pesticide use and prostate cancer risk by lipid metabolism variants where FDR 𝑃 interaction <0.2¹.

Pesticide

Gene

SNP

SNP region

Genotype

Nonexposed

Low exposed

High exposed

Exposure trend

𝑃 interaction^2

FDR 𝑃 interaction^1,2

Case/control

Case/control

OR^2

(95%CI)^2

𝑃^2

Case/control

OR^2

(95%CI)^2

𝑃^2

OR^2

(95%CI)^2

𝑃^2

ALOXE3; (epidermis-type lipoxygenase 3)

rs3027208

IVS7+369G>A

CC; CT+TT

307/576; 99/227

REF; REF

102/195; 43/55

0.99; 1.86

(0.74–1.31); (1.16–2.99)

0.93; 0.01

81/188; 50/60

0.81; 2.00

(0.60–1.10); (1.28–3.15)

0.18; 0.00

0.91; 1.45

(0.79–1.05); (1.16–1.81)

0.22; 0.001

0.001

0.08

Terbufos

SEC14L2; (SEC14-like protein 2)

rs2072159

IVS2−93G>A

GG; AG+AA

201/457; 204/342

REF; REF

83/139; 61/108

1.38; 0.97

(0.99–1.92); (0.67–1.40)

0.05; 0.88

82/132; 47/115

1.43; 0.70

(1.03–1.99); (0.48–1.03)

0.03; 0.07

1.21; 0.86

(1.03–1.42); (0.71–1.03)

0.02; 0.10

0.003

0.15

ADIPOR1; (adiponectin receptor 1)

rsl2733285

IVS1−1748G>A

CC; CT+TT

183/421; 223/372

REF; REF

74/123; 70/126

1.39; 0.96

(0.98–1.96); (0.68–1.35)

0.07; 0.80

80/131; 51/117

1.43; 0.75

(1.02–1.99); (0.52–1.10)

0.04; 0.14

1.21; 0.88

(1.03–1.43); (0.74–1.05)

0.02; 0.16

0.01

0.18

¹Accounts for 220 SNPs included in interaction analyses.
²Risk estimates adjusted for age and state.