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Journal of Cancer Epidemiology
Volume 2013, Article ID 549041, 6 pages
Clinical Study

Immunohistochemical Analysis of Vimentin in Oral Submucous Fibrosis

1Department of Oral & Maxillofacial Pathology, Vyas Dental College and Hospital, Jodhpur, Rajasthan 342011, India
2Department of Oral Medicine & Radiology, Vyas Dental College and Hospital, Jodhpur 342011, India
3Department of Oral & Maxillofacial Pathology, Nair Hospital Dental College, Mumbai 400008, India
4Department of Oral & Maxillofacial Pathology, PMNM Dental College & Hospital, Bagalkot 587101, India

Received 25 February 2013; Revised 11 May 2013; Accepted 28 May 2013

Academic Editor: L. A. Liotta

Copyright © 2013 Meghanand T. Nayak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Oral submucous fibrosis (OSF), a precancerous condition, is characterized by abnormal accumulation of collagen fibers in oral submucosa. Vimentin is a Class 2 intermediate filament (IF) and primarily expressed in cells of mesenchymal origin. Vimentin is also found to be involved in cell growth, cell cycling, and tumour differentiation. Objective. The purpose of the study was to compare the expression of vimentin in various histological grades of OSF. Materials and Methods. To assess the immunohistochemical expression of vimentin in 20 mild cases of OSF, 20 severe cases of OSF, and ten cases of normal oral buccal mucosa. Results. The overall staining intensity of vimentin significantly increased statistically ( ) in OSF cases over normal control. A significant increase in the staining intensity of vimentin was also noted in the fibroblasts of severe cases of OSF ( ). Conclusion. Considering the marked vimentin expression in the present study, future studies should include cytoskeleton IF and other filaments in the fibroblasts of OSF.