Breast Cancer Pathology, Receptor Status, and Patterns of Metastasis in a Rural Appalachian Population

Table 2

First site of distant metastases and median disease free interval in 95 patients.

Anatomic site	𝑛 (%)	Median disease free interval, months (CI)	𝑃 value
Bone	42 (44.2)	19.9 (3.2–27.5)	0.079^†
Viscera	53 (55.8)	13.9 (9.1–20.3)
Liver*	21/53 (39.6)	20.9 (6.4–26.4)	<0.024^‡
Lung*	20/53 (37.7)	9.6 (2.3–14.1)
Brain	11/53 (20.8)	25.8 (8.1–40.1)
Ovary	1/53 (1.9)	13.3

∗There were 8 patients who presented simultaneously with liver and lung metastases; according to protocol, liver took precedence when assigning first metastatic site.
^†𝑃 represents a comparison between bone and combined visceral sites using log-rank test.
^‡𝑃 represents a comparison within visceral sites excluding the ovary using log-rank test.
CI denotes lower and upper 95% confidence intervals.