Breast Cancer Pathology, Receptor Status, and Patterns of Metastasis in a Rural Appalachian Population

Table 3

Pattern of metastatic spread for tumors with known steroid receptor status and HER2 overexpression.

Category	Number of cases	ER-; positive	PR-; positive	HER2; overexpression*	Triple-; negative
No metastases	488	345 (70.7)	316 (64.7)	98 (20.1)	107 (21.9)
Metastases
Bone	42	33 (78.6)	29 (69.0)	5 (13.9)	6 (14.3)
Viscera	53	22 (41.5)	18 (33.9)	6 (12.0)	22 (41.5)
No metastases versus mestastases		0.0005	0.0004	0.245	0.002
Bone versus viscera		0.0003	0.0008	0.796	0.003

∗HER2 expression was unknown in 10 cases.