Adipokines Do Not Mediate the Association of Obesity and Colorectal Adenoma
Table 1
Descriptive characteristics for TREC adenoma study.
Characteristics Mean (SD) or (%)
African American adenoma cases ()
Caucasian adenoma cases ()
value
African American adenoma-free controls ()
Caucasian adenoma-free controls ()
value
Age (years)
58.2 (8.4)
57.4 (8.1)
0.35
54.7 (8.6)
54.4 (8.6)
0.50
Male
71 (40.6%)
113 (52.1%)
0.02
91 (24.1%)
240 (36.9%)
<0.001
Body mass index (BMI) (kg/m2)
31.7 (7.3)
29.1 (5.5)
<0.001
32.3 (7.4)
28.0 (5.7)
<0.001
BMI categories
≤24.9
26 (14.9%)
45 (20.7%)
0.01
45 (11.9%)
207 (31.9%)
<0.001
25.0–29.9
59 (33.7%)
94 (43.3%)
122 (32.3%)
243 (37.4%)
30.0–34.9
45 (25.7%)
48 (22.1%)
91 (24.1%)
126 (19.4%)
35.0–39.9
24 (13.7%)
20 (9.2%)
71 (18.8%)
44 (6.8%)
≥40.0
21 (12.0%)
10 (4.6%)
49 (13.0%)
30 (4.6%)
Waist-to-hip ratio (WHR)
0.97 (0.09)
0.92 (0.09)
<0.001
0.93 (0.09)
0.90 (0.09)
<0.001
Waist circumference (cm)
105.0 (17.1)
99.6 (16.0)
0.001
104.1 (16.7)
95.1 (16.1)
<0.001
Abdominal obesity1
125 (71.4%)
124 (57.1%)
0.003
279 (73.8%)
318 (48.9%)
<0.001
Adiponectin (ng/mL)
7757.0 (5437.4)
10577.1 (5732.9)
<0.001
8017.6 (5166.1)
11637.9 (6443.4)
<0.001
Leptin (pg/mL)
25341.3 (23384.2)
16012.3 (17593.0)
<0.001
31458.6 (25700.5)
16158.4 (16707.8)
<0.001
Fasting glucose (mg/dL)
99.9 (29.8)
86.2 (17.0)
<0.001
94.0 (36.8)
85.1 (24.0)
<0.001
Insulin (µIU/mL)
15.3 (61.2)
7.7 (11.7)
0.11
9.9 (14.1)
6.2 (7.1)
<0.001
Total daily energy expenditure (kj)
10485.2 (3005.5)
10615.1 (2829.2)
0.68
10574.0 (3404.7)
10627.7 (2877.8)
0.81
Diabetes2
44 (25.2%)
17 (7.8%)
<0.001
85 (22.6%)
56 (8.6%)
<0.001
Postmenopausal
81 (46.8%)
73 (33.6%)
0.03
204 (54.3%)
254 (39.1%)
<0.001
NSAID use3
66 (37.7%)
88 (40.6%)
0.57
133 (35.2%)
228 (35.1%)
0.97
Family history of colorectal cancer
29 (16.9%)
58 (27.0%)
0.02
90 (24.4%)
160 (24.8%)
0.87
Pack-years of smoking
20.8 (18.7)
20.3 (19.9)
0.83
14.9 (14.6)
17.2 (22.1)
0.15
Smoking status
Never
52 (29.7%)
97 (44.7%)
<0.001
147 (39.0%)
332 (51.1%)
<0.001
Former
61 (34.9%)
91 (41.9%)
132 (35.0%)
257 (39.5%)
Current
62 (35.4%)
29 (13.4%)
98 (26.0%)
61 (9.4%)
Abdominal obesity defined as waist circumference >88 cm for women and >102 cm for men.
2Diabetes was self-reported.
3NSAID use defined as ever taken aspirin/ibuprofen at least twice per week for >1 month.
