Adipokines Do Not Mediate the Association of Obesity and Colorectal Adenoma

Table 2

Race-stratified mediation analysis [17].

Race	Biomarker	Step  1; (SE)^1	Step  1; value	Step  2; (SE)^2	Step  2; value	Step  3; Sobel mediation; value
African Americans	Leptin	8313.5 (11456.5)	0.47	−0.000005 (0.000005)	0.31	0.56
	Adiponectin	−13743.7 (2515.4)	<0.001	0.000004 (0.000019)	0.84	0.83
Caucasians	Leptin	39913.3 (7003.6)	<0.001	0.000005 (0.000005)	0.36	0.32
	Adiponectin	−14566.5 (2497.2)	<0.001	−0.000016 (0.000015)	0.30	0.29

Linear regression of WHR (independent variable) and adipokine (dependent variable) adjusted for age and sex.
²Logistic regression of adipokine (independent variable) and adenoma (dependent variable) adjusted for age, sex, and WHR.