A Population-Based Study of Childhood Cancer Survivors’ Body Mass Index

Table 3

Relative risks (RR) and 95% confidence intervals (95% CI) of BMI outcomes for all cancers and the five most common cancers versus comparison cohort^a.

	Underweight			Overweight/obese
	(BMI < 18.5)^a,b			(BMI ≥ 25)^a,c
	RR	95% CI	𝑃-value	RR	95% CI	𝑃-value
Female
Comparison cohort (ref)	1			1
All cancers	1.02	1.00–1.04	0.10	0.99	0.94–1.03	0.58
Top five cancers
Lymphoma	1.05	0.98–1.11	0.14	0.94	0.86–1.04	0.24
Epithelial	1.01	0.98–1.05	0.44	0.89	0.82–0.96	0.004
Acute lymphoblastic leukemia^b	1.02	0.96–1.08	0.47	1.07	0.96–1.19	0.22
Central nervous system	1.01	0.96–1.07	0.69	1.03	0.92–1.16	0.58
Germ	n/a^d			0.97	0.82–1.14	0.70
Male
Comparison cohort (ref)	1			1
All cancers	1.01	1.00–1.02	0.16	1.02	0.98–1.07	0.28
Top five cancers
Lymphoma	1.00	0.98–1.01	0.74	1.03	0.95–1.11	0.52
Epithelial	1.01	0.98–1.04	0.61	1.00	0.89–1.13	0.99
Acute lymphoblastic leukemia	1.01	0.98–1.04	0.58	1.03	0.93–1.13	0.54
Central nervous system	n/a^d			1.12	1.01–1.23	0.03
Germ	1.04	0.99–1.09	0.10	0.91	0.82–1.00	0.06

aModels included both main effects and an interaction term for continuous birth year and categorical age at BMI and were adjusted for year at BMI measurement. For females, the full cancer model includes 𝑁=518 cancers and 𝑁=2665 in the comparison. For males, the full cancer model includes 𝑁=542 cancers and 𝑁=2745 in the comparison.
^bUnderweight versus Normal-Obese.
^cOverweight/Obese versus Underweight-Normal.
^dFemale germ cell and male central nervous system not estimated as no cases were underweight in these cancer groups.
Bold indicates significant at 𝛼<0.05.