A Population-Based Study of Childhood Cancer Survivors’ Body Mass Index
Table 4
Relative Risks (RR) and 95% Confidence Intervals (95% CI) of BMI outcomes for survivors by age at diagnosis, race, and treatment therapy.
Main analysesa,c
Secondary analysisb,c
Underweight
Overweight/obese
Obese
RR
95% CI
-value
RR
95% CI
-value
RR
95% CI
-value
Female
Diagnosis age
16–20 (ref)
1
1
1
11–15
0.98
0.93–1.04
0.56
1.04
0.94–1.16
0.42
1.05
0.98–1.13
0.13
5–10
0.95
0.89–1.02
0.16
1.14
1.00–1.31
0.05
1.10
1.01–1.21
0.04
≤4
0.97
0.90–1.04
0.37
1.14
0.99–1.31
0.06
1.12
1.03–1.22
0.007
Race/ethnicity
Other (ref)
1
1
1
White, Non-Hispanic
1.09
1.04–1.15
0.001
0.95
0.75–1.21
0.67
1.11
1.04–1.19
0.002
Cancer therapy
Surgery (ref)
1
1
1
None or not documented
1.00
0.95–1.06
0.89
1.08
0.93–1.25
0.32
0.93
0.85–1.02
0.14
Chemotherapy
1.03
0.96–1.11
0.35
0.98
0.86–1.11
0.74
0.96
0.89–1.04
0.35
Radiation
1.06
0.97–1.16
0.17
0.99
0.84–1.15
0.88
0.97
0.88–1.08
0.62
Chemotherapy + radiation
1.01
0.96–1.07
0.67
1.15
0.99–1.34
0.06
0.97
0.88–1.07
0.62
Chemotherapy + surgery
1.08
0.94–1.24
0.26
1.05
0.87–1.27
0.61
0.90
0.84–0.96
0.001
Radiation + surgery
1.01
0.90–1.13
0.87
1.17
0.95–1.42
0.13
1.18
0.98–1.41
0.08
Chemotherapy + radiation + surgery
1.11
0.95–1.30
0.19
0.95
0.78–1.16
0.61
0.98
0.88–1.09
0.68
Male
Diagnosis age
16–20 (ref)
1
1
1
11–15
1.00
0.97–1.03
0.92
1.07
0.94–1.21
0.30
1.01
0.90–1.12
0.91
5–10
0.98
0.95–1.02
0.43
1.00
0.88–1.15
0.95
0.95
0.85–1.06
0.33
≤4
1.01
0.97–1.05
0.56
1.11
0.96–1.27
0.15
0.96
0.85–1.08
0.49
Race/ethnicity
Other (ref)
1
1
1
White, Non-Hispanic
0.94
0.80–1.10
0.44
0.94
0.72–1.22
0.64
1.03
0.93–1.28
0.79
Cancer therapy
Surgery (ref)
1
1
1
Chemotherapy
0.99
0.95–1.04
0.78
0.99
0.88–1.13
0.93
1.03
0.92–1.15
0.63
Radiation
1.00
0.96–1.04
0.94
0.98
0.83–1.16
0.83
1.14
0.97–1.34
0.11
Not documented/no treatment
1.03
0.97–1.10
0.28
1.01
0.86–1.19
0.88
1.09
0.94–1.26
0.23
Chemotherapy + radiation
0.99
0.94–1.04
0.71
0.91
0.78–1.05
0.21
0.97
0.86–1.09
0.59
Chemotherapy + surgery
0.99
0.94–1.04
0.74
1.01
0.85–1.20
0.93
1.00
0.87–1.14
0.98
Radiation + surgery
0.97
0.93–1.00
0.09
0.98
0.78–1.21
0.83
1.01
0.84–1.22
0.92
Chemotherapy + radiation + surgery
0.96
0.93–1.00
0.05
1.06
0.87–1.29
0.57
1.05
0.89–1.24
0.55
Main analyses include two models; the first model compared underweight to all other BMI categories. The second model compared overweight/obese as one category to all other BMI categories.
bSecondary analysis model compared obese to all other BMI categories.
cModels included both main effects and an interaction term for continuous birth year and categorical age at BMI and were adjusted for year at BMI measurement. Bold indicates significant at .
