Journal of Cancer Epidemiology / 2014 / Article / Tab 2

Research Article

Characterization of Pediatric Acute Lymphoblastic Leukemia Survival Patterns by Age at Diagnosis

Table 2

Hazard risk of mortality associated with age at diagnosis in pediatric ALL patients (1973–2009 SEER dataset) in an univariable Cox proportional hazard model.

VariablesHazard ratio (HR)95% C.I.

Age at diagnosis (yrs)
 <11.00Reference
 1–40.180.15, 0.20<0.0001
 5–90.260.22, 0.30<0.0001
 10–140.440.38, 0.51<0.0001
 15–190.690.59, 0.80<0.0001
Sex
 Female1.00Reference
 Male1.291.20, 1.39<0.0001
Race
 Caucasian1.00Reference
 AA1.441.27, 1.62<0.0001
Primary tumor sites
 11.00Reference
 ≥21.180.92, 1.520.1950
Immunophenotype
 T-cell1.00Reference
 B-cell, B-precursor0.570.49, 0.65<0.0001
Radiation
 No1.00Reference
 Yes1.661.53, 1.79<0.0001
Year of diagnosis
 1973–19771.00 Reference
 1978–19820.700.61, 0.80<0.0001
 1983–19870.560.49, 0.65<0.0001
 1988–19920.380.33, 0.44<0.0001
 1993–19970.320.28, 0.36<0.0001
 1998–20020.290.26, 0.33<0.0001
 2003–20070.240.21, 0.27<0.0001
 2008-20090.190.14, 0.25<0.0001

C.I.: confidence interval.

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