Impact of Diabetes Status and Medication on Presentation, Treatment, and Outcome of Stage II Colon Cancer Patients

Table 3

Operative morbidity and mortality, adjuvant treatment commenced, and completed details of nondiabetes versus diabetes patients, including metformin and insulin treated subsets.

	No diabetes	Diabetes	Metformin group	Insulin group
Renal function
μmol/L, mean Cr^a	N/A	87	80	92
(%) eGFR < 60^b	N/A	49 (22%)	17 (18%)	32 (25%)
Surgical complications, (%)	185 (21.1)	67 (27.8)	31 (31.3)	7 (29.2)
Operative mortality, (%)	14 (1.6)	5 (2.1)	1 (1.0)	1 (4.2)
Adjuvant chemotherapy commenced, (%)	217 (24.8)	33 (13.7)	11 (11.1)	4 (16.7)
Adjuvant chemotherapy completed, (%)	593 (67.8)	168 (69.7)	63 (63.4)	18 (75)

^aSerum creatinine.
^bNumber and percentage of patients with estimated glomerular filtration rate less than 60 mL/min/1.73 m².