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Journal of Cancer Epidemiology
Volume 2015, Article ID 643020, 10 pages
http://dx.doi.org/10.1155/2015/643020
Review Article

Colorectal Cancer in Iran: Molecular Epidemiology and Screening Strategies

1Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3Center of Excellent for Biodiversity, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
4Department of Medicine, The University of Kansas Medical School, Molecular Medicine Laboratory, KUMC, Kansas City, KS, USA

Received 13 September 2014; Revised 5 December 2014; Accepted 15 December 2014

Academic Editor: Lidia Larizza

Copyright © 2015 Roya Dolatkhah et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Ansari, M. Mahdavinia, A. Sadjadi et al., “Incidence and age distribution of colorectal cancer in Iran: results of a population-based cancer registry,” Cancer Letters, vol. 240, no. 1, pp. 143–147, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. R. Mundade, T. F. Imperiale, L. Prabhu, P. J. Loehrer, and T. Lu, “Genetic pathways, prevention, and treatment of sporadic colorectal cancer,” Oncogenesis, vol. 1, no. 6, pp. 400–406, 2014. View at Google Scholar
  3. V. Stigliano, L. Sanchez-Mete, and A. Martayan, “Early-onset colorectal cancer: a sporadic or inherited disease?” World Journal of Gastroenterology, vol. 20, no. 35, pp. 12420–12430, 2014. View at Publisher · View at Google Scholar
  4. R. C. Heine-Bröring, R. M. Winkels, J. M. S. Renkema et al., “Dietary supplement use and colorectal cancer risk: a systematic review and meta-analyses of prospective cohort studies,” International Journal of Cancer, 2014. View at Publisher · View at Google Scholar
  5. H. Brim, P. Mokarram, F. Naghibalhossaini et al., “Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study,” Molecular Cancer, vol. 7, article 68, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. M. van Engeland, M. P. Weijenberg, G. M. J. M. Roemen et al., “Effects of dietary folate and alcohol intake on promoter methylation in sporadic colorectal cancer: the Netherlands cohort study on diet and cancer,” Cancer Research, vol. 63, no. 12, pp. 3133–3137, 2003. View at Google Scholar · View at Scopus
  7. R. G. Hardy, S. J. Meltzer, and J. A. Jankowski, “ABC of colorectal cancer: molecular basis for risk factors,” British Medical Journal, vol. 321, no. 7265, pp. 886–889, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. C. N. Arnold, A. Goel, H. E. Blum, and C. R. Boland, “Molecular of colorectal cancer: implications for molecular diagnosis,” Cancer, vol. 104, no. 10, pp. 2035–2047, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. J. R. Jass, M. D. Walsh, M. Barker, L. A. Simms, J. Young, and B. A. Leggett, “Distinction between familial and sporadic forms of colorectal cancer showing DNA microsatellite instability,” European Journal of Cancer, vol. 38, no. 7, pp. 858–866, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. J. R. Jass, “Classification of colorectal cancer based on correlation of clinical, morphological and molecular features,” Histopathology, vol. 50, no. 1, pp. 113–130, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. K. Hemminki, X. Li, and C. Dong, “Second primary cancers after sporadic and familial colorectal cancer,” Cancer Epidemiology Biomarkers and Prevention, vol. 10, no. 7, pp. 793–798, 2001. View at Google Scholar · View at Scopus
  12. S. Kirzin, L. Marisa, R. Guimbaud et al., “Sporadic early-onset colorectal cancer is a specific sub-type of cancer: a morphological, molecular and genetics study,” PLoS ONE, vol. 9, no. 8, Article ID e103159, 2014. View at Publisher · View at Google Scholar
  13. R. Malekzadeh, F. Bishehsari, M. Mahdavinia, and R. Ansari, “Epidemiology and molecular genetics of colorectal cancer in Iran: a review,” Archives of Iranian Medicine, vol. 12, no. 2, pp. 161–169, 2009. View at Google Scholar · View at Scopus
  14. D. Colussi, G. Brandi, F. Bazzoli, and L. Ricciardiello, “Molecular pathways involved in colorectal cancer: implications for disease behavior and prevention,” International Journal of Molecular Sciences, vol. 14, no. 8, pp. 16365–16385, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Al-Sohaily, A. Biankin, R. Leong, M. Kohonen-Corish, and J. Warusavitarne, “Molecular pathways in colorectal cancer,” Journal of Gastroenterology and Hepatology, vol. 27, no. 9, pp. 1423–1431, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. C. Kin, E. Kidess, G. A. Poultsides, B. C. Visser, and S. S. Jeffrey, “Colorectal cancer diagnostics: biomarkers, cell-free DNA, circulating tumor cells and defining heterogeneous populations by single-cell analysis,” Expert Review of Molecular Diagnostics, vol. 13, no. 6, pp. 581–599, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. U. Malapelle, C. Carlomagno, C. De Luca, C. Bellevicine, and G. Troncone, “KRAS testing in metastatic colorectal carcinoma: challenges, controversies, breakthroughs and beyond,” Journal of Clinical Pathology, vol. 67, no. 1, pp. 1–9, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. H. R. Hagland, M. Berg, I. W. Jolma, A. Carlsen, and K. Søreide, “Molecular pathways and cellular metabolism in colorectal cancer,” Digestive Surgery, vol. 30, no. 1, pp. 12–25, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. V. H. Chong, M. S. Abdullah, P. U. Telisinghe, and A. Jalihal, “Colorectal cancer: incidence and trend in Brunei Darussalam,” Singapore Medical Journal, vol. 50, no. 11, pp. 1085–1089, 2009. View at Google Scholar · View at Scopus
  20. J. Jackson-Thompson, F. Ahmed, R. R. German, S.-M. Lai, and C. Friedman, “Descriptive epidemiology of colorectal cancer in the United States, 1998–2001,” Cancer, vol. 107, no. 5, pp. 1103–1111, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. P. S. Pahlavan and R. Kanthan, “The epidemiology and clinical findings of colorectal cancer in Iran,” Journal of Gastrointestinal and Liver Diseases, vol. 15, no. 1, pp. 15–19, 2006. View at Google Scholar · View at Scopus
  22. F. Ruthotto, F. Papendorf, G. Wegener et al., “Participation in screening colonoscopy in first-degree relatives from patients with colorectal cancer,” Annals of Oncology, vol. 18, no. 9, pp. 1518–1522, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. A. S. Behl and S. D. Ramsey, “KRAS and BRAF mutation screening in metastatic colorectal cancer costly in relation to benefits,” Journal of the National Cancer Institute, vol. 104, no. 23, Article ID djs518, 2012. View at Publisher · View at Google Scholar
  24. M. Mohebbi, K. Nourijelyani, M. Mahmoudi et al., “Time to occurrence and age distribution of digestive cancers in northern Iran,” Iranian Journal of Public Health, vol. 37, no. 1, pp. 8–19, 2008. View at Google Scholar · View at Scopus
  25. M. Barouni, M. H. Larizadeh, A. Sabermahani, and H. Ghaderi, “Markov's modeling for screening strategies for colorectal cancer,” Asian Pacific Journal of Cancer Prevention, vol. 13, no. 10, pp. 5125–5129, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. F. Hajmanoochehri, S. Asefzadeh, A. M. Kazemifar, and M. Ebtehaj, “Clinicopathological features of colon adenocarcinoma in Qazvin, Iran: a 16 year study,” Asian Pacific Journal of Cancer Prevention, vol. 15, no. 2, pp. 951–955, 2014. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Kolahdoozan, A. Sadjadi, A. R. Radmard, and H. Khademi, “Five common cancers in Iran,” Archives of Iranian Medicine, vol. 13, no. 2, pp. 143–146, 2010. View at Google Scholar · View at Scopus
  28. R. Ansari, H. Amjadi, N. Norozbeigi et al., “Survival analysis of colorectal cancer in patients underwent surgical operation in Shariati and Mehr Hospital-Tehran, in a retrospective study,” Govaresh, vol. 12, no. 1, pp. 7–15, 2007. View at Google Scholar
  29. S. M. H. Emami, A. M. Fatemi, Z. Farajzadegan, and S. M. Movahed-Abtahi, “Epidemiology of colorectal cancer in Isfahan province,” Govaresh, vol. 10, no. 3, pp. 134–139, 2005. View at Google Scholar
  30. A. Moradi, M. Khayamzadeh, M. M. Guya et al., “Survival of colorectal cancer in Iran,” Asian Pacific Journal of Cancer Prevention, vol. 10, no. 4, pp. 583–586, 2009. View at Google Scholar · View at Scopus
  31. M. R. Rouhollahi, M. A. Mohagheghi, N. Mohammadrezai et al., “Situation analysis of the national comprehensive cancer control program (2013) in the I. R. of Iran; assessment and recommendations based on the IAEA imPACT mission,” Archives of Iranian Medicine, vol. 17, no. 4, pp. 222–231, 2014. View at Google Scholar · View at Scopus
  32. R. Mahmodlou, P. Mohammadi, and N. Sepehrvand, “Colorectal cancer in northwestern Iran,” ISRN Gastroenterology, vol. 2012, Article ID 968560, 4 pages, 2012. View at Publisher · View at Google Scholar
  33. A. Safaee, S. R. Fatemi, S. Ashtari, M. Vahedi, B. Moghimi-Dehkordi, and M. R. Zali, “Four years incidence rate of colorectal cancer in Iran: a survey of national cancer registry data—implications for screening,” Asian Pacific Journal of Cancer Prevention, vol. 13, no. 6, pp. 2695–2698, 2012. View at Publisher · View at Google Scholar · View at Scopus
  34. M. H. Somi, M. Golzari, S. Farhang, S. Naghashi, and L. Abdollahi, “Gastrointestinal cancer incidence in East Azerbaijan, Iran: update on 5 year incidence and trends,” Asian Pacific Journal of Cancer Prevention, vol. 15, no. 9, pp. 3945–3949, 2014. View at Publisher · View at Google Scholar
  35. M. H. Somi, S. Farhang, S. K. Mirinezhad, S. Naghashi, M. Seif-Farshad, and M. Golzari, “Cancer in East Azerbaijan, Iran: results of a population-based cancer registry,” Asian Pacific Journal of Cancer Prevention, vol. 9, no. 2, pp. 327–330, 2008. View at Google Scholar · View at Scopus
  36. International Agency for Research on Cancer (IARC), “GLOBOCAN,” World Cancer Report, 2012, http://globocan.iarc.fr. View at Google Scholar
  37. M. Mahdavinia, F. Bishehsari, R. Ansari et al., “Family history of colorectal cancer in Iran,” BMC Cancer, vol. 5, article 112, 2005. View at Publisher · View at Google Scholar · View at Scopus
  38. S. M. Mousavi, M. M. Gouya, R. Ramazani, M. Davanlou, N. Hajsadeghi, and Z. Seddighi, “Cancer incidence and mortality in Iran,” Annals of Oncology, vol. 20, no. 3, pp. 556–563, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. A. Sadjadi, R. Malekzadeh, M. H. Derakhshan et al., “Cancer occurrence in Ardabil: results of a population-based cancer registry from Iran,” International Journal of Cancer, vol. 107, pp. 113–118, 2003. View at Google Scholar
  40. S. Alireza, N. Mehdi, M. M. Ali, M.-J. Alireza, M. Reza, and D. M. Parkin, “Cancer occurrence in Iran in 2002, an international perspective,” Asian Pacific Journal of Cancer Prevention, vol. 6, no. 3, pp. 359–363, 2005. View at Google Scholar · View at Scopus
  41. S. V. Hosseini, A. Izadpanah, and H. Yarmohammadi, “Epidemiological changes in colorectal cancern in Shiraz, Iran: 1980–2000,” ANZ Journal of Surgery, vol. 74, no. 7, pp. 547–549, 2004. View at Publisher · View at Google Scholar · View at Scopus
  42. B. Yazdizadeh, A. M. Jarrahi, H. Mortazavi, M. A. Mohagheghi, S. Tahmasebi, and A. Nahvijo, “Time trends in the occurrence of major GI cancers in Iran,” Asian Pacific Journal of Cancer Prevention, vol. 6, no. 2, pp. 130–134, 2005. View at Google Scholar · View at Scopus
  43. M. S. Fazeli, M. G. Adel, and A. H. Lebaschi, “Colorectal carcinoma: a retrospective, descriptive study of age, gender, subsite, stage, and differentiation in iran from 1995 to 2001 as observed in Tehran University,” Diseases of the Colon & Rectum, vol. 50, no. 7, pp. 990–995, 2007. View at Publisher · View at Google Scholar · View at Scopus
  44. S. Azadeh, B. Moghimi-Dehkordi, S. R. Fatemi, M. A. Pourhoseingholi, S. Ghiasi, and M. R. Zali, “Colorectal cancer in Iran: an epidemiological study,” Asian Pacific Journal of Cancer Prevention, vol. 9, no. 1, pp. 123–126, 2008. View at Google Scholar · View at Scopus
  45. M. Shahrier and D. J. Ahnen, “Colorectal cancer survival in Europe: the Will Rogers phenomenon revisited,” Gut, vol. 47, no. 4, pp. 463–464, 2000. View at Publisher · View at Google Scholar · View at Scopus
  46. M. E. Akbari and Coworkers, Iran Cancer Report, Cancer Research Center, Shahid Beheshti University, Tehran, Iran, 2008.
  47. M. M. Haghighi, M. Vahedi, S. R. Mohebbi, M. A. Pourhoseingholi, S. R. Fatemi, and M. R. Zali, “Comparison of survival between patients with hereditary non-polyposis colorectal cancer (HNPCC) and sporadic colorectal cancer,” Asian Pacific Journal of Cancer Prevention, vol. 10, no. 3, pp. 209–212, 2009. View at Google Scholar · View at Scopus
  48. M. Aryaie, G. Roshandel, S. Semnani et al., “Predictors of colorectal cancer survival in golestan, Iran: a population-based study,” Epidemiology and Health, vol. 35, Article ID e2013004, 2013. View at Publisher · View at Google Scholar
  49. R. M. Hoffman, D. K. Espey, R. L. Rhyne et al., “Colorectal cancer incidence and mortality disparities in New Mexico,” Journal of Cancer Epidemiology, vol. 2014, Article ID 239619, 8 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  50. E. Borràs, I. Jurado, I. Hernan et al., “Clinical pharmacogenomic testing of KRAS, BRAF and EGFR mutations by high resolution melting analysis and ultra-deep pyrosequencing,” BMC Cancer, vol. 11, article 406, 2011. View at Publisher · View at Google Scholar
  51. F. Naghibalhossaini, H. M. Hosseini, P. Mokarram, and M. Zamani, “High frequency of genes' promoter methylation, but lack of BRAF V600E Mutation among Iranian colorectal cancer patients,” Pathology and Oncology Research, vol. 17, no. 4, pp. 819–825, 2011. View at Publisher · View at Google Scholar · View at Scopus
  52. S. D. Richman, M. T. Seymour, P. Chambers et al., “KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: results from the MRC FOCUS trial,” Journal of Clinical Oncology, vol. 27, no. 35, pp. 5931–5937, 2009. View at Publisher · View at Google Scholar · View at Scopus
  53. F. Bishehsari, M. Mahdavinia, R. Malekzadeh et al., “Patterns of K-ras mutation in colorectal carcinomas from Iran and Italy (a Gruppo Oncologico dell'Italia Meridionale study): influence of microsatellite instability status and country of origin,” Annals of Oncology, vol. 17, no. 7, pp. vii91–vii96, 2006. View at Publisher · View at Google Scholar · View at Scopus
  54. S. Sobhani, M. Ghaffarpour, Z. Mostakhdemin Hosseini, F. Kamali, Z. Nour Mohammadi, and M. Houshmand, “The prevalence of common mutation frequency in KRAS codons 12, 13 in Iranian colorectal cancer patients,” Genetics in the 3rd Millennium, vol. 8, no. 2, pp. 2011–2018, 2010. View at Google Scholar
  55. H. Zhang, J. Song, H. Ren et al., “Detection of low-abundance KRAS mutations in colorectal cancer using microfluidic capillary electrophoresis-based restriction fragment length polymorphism method with optimized assay conditions,” PLoS ONE, vol. 8, no. 1, Article ID e54510, 2013. View at Publisher · View at Google Scholar · View at Scopus
  56. M. C. Hanna, C. Go, C. Roden et al., “Colorectal cancers from distinct dncestral populations show variations in BRAF mutation frequency,” PLoS ONE, vol. 8, no. 9, Article ID e74950, 2013. View at Publisher · View at Google Scholar · View at Scopus
  57. A. L. Nejad and M. M. Yaghoobi, “Mutation analysis of TP53 tumor suppressor gene in colorectal cancer in patients from Iran (Kerman Province),” Iranian Journal of Basic Medical Sciences, vol. 14, no. 6, pp. 683–690, 2012. View at Google Scholar
  58. M. Mahdavinia, F. Bishehsari, F. Verginelli et al., “P53 mutations in colorectal cancer from Northern Iran: relationships with site of tumor origin, microsatellite instability and K-ras mutations,” Journal of Cellular Physiology, vol. 216, no. 2, pp. 543–550, 2008. View at Publisher · View at Google Scholar · View at Scopus
  59. M.-R. Ghavam-Nasiri, E. Rezaei, K. Ghafarzadegan, M. Seilanian-Toosi, and H. Malekifard, “Expression of p53 in colorectal carcinoma: correlation with clinicopathologic features,” Archives of Iranian Medicine, vol. 10, no. 1, pp. 38–42, 2007. View at Google Scholar · View at Scopus
  60. R. Golmohammadi, M. J. Namazi, M. Nikbakht, M. Salehi, and M. H. Derakhshan, “Characterization and prognostic value of mutations in exons 5 and 6 of the p53 gene in patients with colorectal cancers in central Iran,” Gut and Liver, vol. 7, no. 3, pp. 295–302, 2013. View at Publisher · View at Google Scholar · View at Scopus
  61. A. Russo, V. Bazan, B. Iacopetta, D. Kerr, T. Soussi, and N. Gebbia, “The TP53 colorectal cancer international collaborative study on the prognostic and predictive significance of p53 mutation: influence of tumor site, type of mutation, and adjuvant treatment,” Journal of Clinical Oncology, vol. 23, no. 30, pp. 7518–7528, 2005. View at Publisher · View at Google Scholar · View at Scopus
  62. D. W. Kim, I. J. Kim, H. C. Kang et al., “Mutation spectrum of the APC gene in 83 Korean FAP families,” Human Mutation., vol. 26, no. 3, article 281, 2005. View at Google Scholar · View at Scopus
  63. S. M. H. Kashfi, F. B. Farahbakhsh, M. Golmohammadi et al., “Frameshift mutations (deletion at codon 1309 and codon 849) in the APC gene in Iranian FAP patients: a case series and review of the literature,” International Journal of Molecular and Cellular Medicine, vol. 3, no. 3, pp. 196–202, 2014. View at Google Scholar
  64. M. Hasanpour, H. Galehdari, A. Masjedizadeh, and N. Ajami, “A unique profile of adenomatous polyposis coli gene mutations in Iranian patients suffering sporadic colorectal cancer,” Cell Journal, vol. 16, no. 1, pp. 17–24, 2014. View at Google Scholar · View at Scopus
  65. M. Hasanpour, H. Galehdari, and A. Masjedizadeh, “Low mutaion rate in Exon 15 of the APC gene in patients affecting sporadic colorectal cancer in the Khuzestan province,” Cell Journal (Yakhteh), vol. 12, no. 1, p. 49, 2011 (Persian). View at Google Scholar
  66. M. M. Haghighi, G. R. Javadi, K. Parivar et al., “Frequent MSI mononucleotide markers for diagnosis of hereditary nonpolyposis colorectal cancer,” Asian Pacific Journal of Cancer Prevention, vol. 11, no. 4, pp. 1033–1035, 2010. View at Google Scholar · View at Scopus
  67. M. Moghbeli, O. Moaven, E. Dadkhah et al., “High frequency of microsatellite instability in sporadic colorectal cancer patients in Iran,” Genetics and Molecular Research, vol. 10, no. 4, pp. 3520–3529, 2011. View at Publisher · View at Google Scholar · View at Scopus
  68. H. Galehdari, A. A. Shadmehr, M. Kalantar et al., “Molecular analysis of microsatellite instability in hereditary non polyposis colon carcinoma patients from North-East Iran,” Iranian Journal of Pathology, vol. 4, no. 1, pp. 26–31, 2009. View at Google Scholar
  69. A. I. Shemirani, M. M. Haghighi, S. M. Zadeh et al., “Simplified MSI marker panel for diagnosis of colorectal cancer,” Asian Pacific Journal of Cancer Prevention, vol. 12, no. 8, pp. 2101–2104, 2011. View at Google Scholar · View at Scopus
  70. M. Salehi, S. Amani, S. Javan et al., “Evaluation of MLH1 and MSH2 gene mutations in a subset of Iranian families with hereditary nonpolyposis colorectal cancer (HNPCC),” Journal of Sciences, Islamic Republic of Iran, vol. 20, no. 1, pp. 7–12, 2009. View at Google Scholar
  71. E. Fattahi, M. H. Somi, E. Ebrahimzade et al., “Evaluation of relationship between serum levels of tumor markers (CEA, CA19-9) with diagnosis, pathological finding and staging in colorectal carcinoma,” Medical Journal of Tabriz University of Medical Sciences, vol. 33, no. 6, pp. 68–74, 2012. View at Google Scholar
  72. E. Eftekhar and F. Naghibalhossaini, “Carcinoembryonic antigen expression level as a predictive factor for response to 5-fluorouracil in colorectal cancer,” Molecular Biology Reports, vol. 41, no. 1, pp. 459–466, 2014. View at Publisher · View at Google Scholar · View at Scopus
  73. C. S. Fuchs, E. L. Giovannucci, G. A. Colditz, D. J. Hunter, F. E. Speizer, and W. C. Willett, “A prospective study of family history and the risk of colorectal cancer,” The New England Journal of Medicine, vol. 331, no. 25, pp. 1669–1674, 1994. View at Publisher · View at Google Scholar · View at Scopus
  74. G. Barzin, M. R. Ostovaneh, S. Tayebi, H. Vahedi, and R. Ansari, “Screening colonoscopy in first-degree relatives of patients with colorectal cancer,” Archives of Iranian Medicine, vol. 17, no. 2, pp. 115–117, 2014. View at Google Scholar · View at Scopus
  75. M. A. Pourhoseingholi and M. R. Zali, “Colorectal cancer screening: time for action in Iran,” World Journal of Gastrointestinal Oncology, vol. 4, no. 4, pp. 82–83, 2012. View at Publisher · View at Google Scholar
  76. A. Safaee, B. Moghimi-Dehkordi, M. A. Pourhoseingholi et al., “Risk of colorectal cancer in relatives: a case control study,” Indian Journal of Cancer, vol. 47, no. 1, pp. 27–30, 2010. View at Publisher · View at Google Scholar · View at Scopus
  77. S. R. Fatemi, S. Shivarani, F. N. Malek et al., “Colonoscopy screening results in at risk Iranian population,” Asian Pacific Journal of Cancer Prevention, vol. 11, no. 6, pp. 1801–1804, 2010. View at Google Scholar · View at Scopus
  78. H. Salimzadeh, H. Eftekhar, R. Majdzadeh, A. Montazeri, and A. Delavari, “Effectiveness of a theory-based intervention to increase colorectal cancer screening among Iranian health club members: a randomized trial,” Journal of Behavioral Medicine, vol. 37, no. 5, pp. 1019–1029, 2013. View at Publisher · View at Google Scholar · View at Scopus
  79. E. Maserat, R. Fatemi, and M. R. Zali, “New perspective for integrated information management in national colorectal cancer screening in Iran,” Asian Pacific Journal of Cancer Prevention, vol. 10, no. 4, pp. 701–706, 2009. View at Google Scholar · View at Scopus
  80. M. Barouni, H. Ghaderi, and M. K. Shahmoradi, “The economic evaluation of screening for colorectal cancer: case of Iran,” Clinical Laboratory, vol. 59, no. 5-6, pp. 667–674, 2013. View at Publisher · View at Google Scholar · View at Scopus
  81. M. R. Abbaszadegan, A. Tavasoli, A. Velayati et al., “Stool-based DNA testing, a new noninvasive method for colorectal cancer screening, the first report from Iran,” World Journal of Gastroenterology, vol. 13, no. 10, pp. 1528–1533, 2007. View at Publisher · View at Google Scholar · View at Scopus
  82. M. R. Zali, “Colorectal cancer-screening in Iran,” Gastroenterology and Hepatology from Bed to Bench, vol. 1, pp. 103–104, 2008. View at Google Scholar