Journal of Cancer Epidemiology / 2015 / Article / Tab 1

Research Article

Increase in Distant Stage Breast Cancer Incidence Rates in US Women Aged 25–49 Years, 2000–2011: The Stage Migration Hypothesis

Table 1

Age-standardized incidence rate for women aged 25–39 years and 40–49 years with invasive breast cancer in SEER registries: annual percent change (APC) by stage at diagnosisa,b.

Stage 2000 2011 2000–2011
NumberRate (CL)NumberRate (CL)NumberRate (CL)APC, % (CL)

Age 25–39 years
Distant1231.4 (1.2, 1.7)2042.5 (2.2, 2.9)19351.9 (1.8, 2.0)5.4 (3.7, 7.2)*
Regional135615.4 (14.6, 16.3)124915.4 (14.5, 16.3)15,25115.2 (14.9, 15.4)−0.4 (−1.1, +0.3)
 IIICb1742.0 (1.7, 2.3)941.1 (0.9, 1.4)15411.5 (1.5, 1.6)−4.5 (−5.5, −3.4)*
 IIIB881.0 (0.8, 1.2)670.8 (0.6, 1.1)9110.9 (0.8, 1.0)−0.9 (−2.3, +0.5)
 IIIA3243.7 (3.3, 4.1)3244.0 (3.6, 4.4)37733.8 (3.6, 3.9)0.5 (−0.9, +2.1)
 IIA, IIB6937.9 (7.3, 8.5)7048.7 (8.1, 9.4)82968.3 (8.1, 8.4)0.2 (−0.6, +0.9)
Localized 133815.3 (14.5, 16.1)130916.1 (15.3, 17.1)15,81315.8 (15.5, 16.0)0.2 (−0.3, +0.8)

Age 40–49 years
Distant3415.7 (5.1, 6.3)4757.7 (7.0, 8.4)48176.4 (6.2, 6.6)3.6 (2.2, 5.1)*
Regional363460.3 (58.3, 62.3)339654.5 (52.7, 56.4)43,47957.7 (57.1, 58.2) −0.9 (−1.2, −0.5)*
 IIICb3756.2 (5.6, 6.9)2634.2 (3.7, 4.8)37955.0 (4.9, 5.2)−3.7 (−4.9, −2.5)*
 IIIB2063.4 (3.0, 3.9)1682.7 (2.3, 3.1)23613.1 (3.0, 3.3)−1.4 (−2.9, +0.2)
 IIIA80913.4 (12.5, 14.4)84013.5 (12.6, 14.5)991613.2 (12.9, 13.4)0.0 (−0.6, +0.6)
 IIA, IIB208334.6 (33.1, 36.1)201532.3 (30.9, 33.8)25,31433.6 (33.2, 34.0)−0.6 (−1.1, −0.1)*
Localized507884.2 (81.9, 86.5)560389.4 (87.1, 91.8) 64,88185.8 (85.1, 86.4) 0.8 (0.3, 1.2)*

aSummary stage 2000 (1988+) [7] (see text).
bSEER breast-adjusted AJCC 6th edition stages IIIC, IIIB, and IIA-B, within regional summary stage cancers [11] (see text).
CL: confidence limits (95%), lower and upper, on rate or on APC.
SEER: Surveillance, Epidemiology, and End Results Program of the National Cancer Institute.
*CL do not include zero.