Table of Contents Author Guidelines Submit a Manuscript
Journal of Cancer Epidemiology
Volume 2015, Article ID 879302, 10 pages
http://dx.doi.org/10.1155/2015/879302
Research Article

Occupational Exposure to Diesel Motor Exhaust and Lung Cancer: A Dose-Response Relationship Hidden by Asbestos Exposure Adjustment? The ICARE Study

1INSERM, Centre de Recherche en Epidémiologie et Santé des Populations (CESP), U1018, Equipe Epidémiologie des Cancers, Gènes et Environnement, Bâtiment 15/16, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif, France
2Faculté de Médecine, Université Paris Est Créteil, 8 rue du Général Sarrail, 94010 Créteil Cedex, France
3Centre Hospitalier Intercommunal, Service de Pneumologie et Pathologie Professionnelle, 40 Avenue de Verdun, 94010 Créteil, France
4Unité Mixte de Recherche Épidémiologique et de Surveillance Transport Travail Environnement (UMRESTTE), Université Claude Bernard Lyon 1, 69373 Lyon, France
5INSERM, Centre de Recherche en Epidémiologie et Santé des Populations (CESP), Unité UMS 011 Equipe Cohortes Épidémiologiques en Population, Bâtiment 15/16, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif, France
6Université de Versailles Saint-Quentin, UMS011, Equipe Cohortes Épidémiologiques en Population, Bâtiment 15/16, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif, France
7INSERM, UMR_S 1136, Institut Pierre Louis d’Epidémiologie et de Santé Publique, 56 Boulevard Vincent Auriol, CS81393, 75646 Paris Cedex 13, France
8UPMC Université de la Sorbonne, Université Paris 06, UMRS 1136, Institut Pierre Louis d’Epidémiologie et de Santé Publique, 56 Boulevard Vincent Auriol, CS81393, 75646 Paris Cedex 13, France
9INSERM, Centre de Recherche en Epidémiologie et Santé des Populations (CESP), U1018, Equipe Epidémiologie des Déterminants Sociaux et Professionnels de la Santé, Bâtiment 15/16, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif, France
10Faculté de Chirurgie Dentaire, Université Paris Descartes, 1 rue Maurice Arnoux, 92120 Montrouge, France
11Registre des Cancers de la Manche, Centre Hospitalier Public du Cotentin, 46 rue Val de Saire, 50102 Cherbourg, France
12Registre des Cancers du Bas-Rhin, Département d’Épidémiologie et de Santé Publique, Faculté de Médecine, Université de Strasbourg, 4 rue Kirschleger, 67085 Strasbourg Cedex, France
13INSERM U1085, IRSET, Campus de Fouillole, BP145, 97154 Pointe à Pitre, Guadeloupe
14Université de Rennes 1, Campus de Fouillole, BP145, 97154 Pointe à Pitre, Guadeloupe

Received 23 February 2015; Revised 13 May 2015; Accepted 14 May 2015

Academic Editor: Yun-Ling Zheng

Copyright © 2015 Mireille Matrat et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. In a French large population-based case-control study we investigated the dose-response relationship between lung cancer and occupational exposure to diesel motor exhaust (DME), taking into account asbestos exposure. Methods. Exposure to DME was assessed by questionnaire. Asbestos was taken into account through a global indicator of exposure to occupational carcinogens or by a specific JEM. Results. We found a crude dose response relationship with most of the indicators of DME exposure, including with the cumulative exposure index. All results were affected by adjustment for asbestos exposure. The dose response relationships between DME and lung cancer were observed among subjects never exposed to asbestos. Conclusions. Exposure to DME and to asbestos is frequently found among the same subjects, which may explain why dose-response relationships in previous studies that adjusted for asbestos exposure were inconsistent.