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Journal of Cancer Epidemiology
Volume 2017, Article ID 6170290, 9 pages
https://doi.org/10.1155/2017/6170290
Research Article

Prevalence of EGFR Mutations in Lung Cancer in Uruguayan Population

1Laboratorio de Glicobiología e Inmunología Tumoral, Institut Pasteur de Montevideo, Montevideo, Uruguay
2Servicio de Oncología Clínica, Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay
3Departamento de Genética, Laboratorio Epidemiología Genética, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay
4Departamento de Inmunobiología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay

Correspondence should be addressed to Nora Berois; yu.ude.ruetsap@siorebn

Received 12 January 2017; Revised 22 May 2017; Accepted 29 May 2017; Published 28 June 2017

Academic Editor: Yun-Ling Zheng

Copyright © 2017 Nora Berois et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Incorporation of molecular analysis of the epidermal growth factor receptor (EGFR) gene into routine clinical practice represents a milestone for personalized therapy of the non-small-cell lung cancer (NSCLC). However, the genetic testing of EGFR mutations has not yet become a routine clinical practice in developing countries. In view of different prevalence of such mutations among different ethnicities and geographic regions, as well as the limited existing data from Latin America, our aim was to study the frequency of major types of activating mutations of the EGFR gene in NSCLC patients from Uruguay. Methods. We examined EGFR mutations in exons 18 through 21 in 289 NSCLC Uruguayan patients by PCR-direct sequencing. Results. EGFR mutations were detected in 53 of the 289 (18.3%) patients, more frequently in women (23.4%) than in men (14.5%). The distribution by exon was similar to that generally reported in the literature. Conclusions. This first epidemiological study of EGFR mutations in Uruguay reveals a wide spectrum of mutations and an overall prevalence of 18.3%. The background ethnic structure of the Uruguayan population could play an important role in explaining our findings.