Prevalence of EGFR Mutations in Lung Cancer in Uruguayan Population

Table 1

Mutations in the EGFR gene.

	Sex	Mutations
		Type of mutation	Exon	Mutation ID (COSMIC)	Nucleotide change	Amino acid change
1	F	Substitution, missense	18	—	c.2132A>G	p.E711G
2	M	Substitution, missense	18	COSM6253	c.2155G>T	p.G719C
1	M	Substitution, missense	18	COSM12371	c.2126A>T	p.E709V
1	M	Substitution, missense	18	—	c.2140A>G	p.K714E
1	M	Substitution, missense	18	COSM1651578	c.2142G>T	p.K714N
1	M	Substitution, missense	19	COSM52931	c.2195T>C	p.I732T
6	F	Deletion, in-frame	19	COSM6223	c.2235_2249del15	p.E746_A750delELREA
3	M	Deletion, in-frame	19	COSM6223	c.2235_2249del15	p.E746_A750delELREA
3	M	Deletion, in-frame	19	COSM6225	c.2236_2250del15	p.E746A_750delELREA
7	F	Deletion, in-frame	19	COSM6225	c.2236_2250del15	p.E746A_750delELREA
1	F	Deletion, in-frame	19	COSM6254	c.2239_2253del15	p.L747-T751delLREAT
1	M	Deletion, in-frame	19	COSM12369	c.2240_2254del15	p.L747_T751delLREAT
1	M	Deletion, in-frame	19	COSM13556	c.2253_2276del24	p.S752_I759delSPKANKEI
5	F	Complex, deletion in-frame	19	COSM12370	c.2240_2257del18	p.L747_P753del>S
2	M	Complex, deletion in-frame	19	COSM12382	c.2239_2248del10>C	p.L747_A750del>P
1	F	Complex, deletion in-frame	19	—	c.2235_2251del17>ATTCCCGT	p.E746_T751del>FPS
1	M	Substitution, missense	20	COSM6241	c.2303G>T	p.S768I
1	F	Substitution, missense	20	COSM13425	c.2305G>A	p.V769M
1	F	Insertion, in-frame	20	—	c.2308_2309insTGG	p.V769_D770insV
2	M	Substitution, missense	20	COSM6240	c.2369C>T	p.T790M
2	F	Substitution, missense	21	COSM22943	c.2543C>T	p.P848L
1	M	Substitution, missense	21	COSM85961	c.2518G>A	p.A840T
6	F	Substitution, missense	21	COSM6224	c.2573T>G	p.L858R
7	M	Substitution, missense	21	COSM6224	c.2573T>G	p.L858R
1	M	Substitution, missense	21	COSM6213	c.2582T>A	p.L861Q

Triple mutation in the same patient. ^&Double mutation in the same patient.