Prevalence of EGFR Mutations in Lung Cancer in Uruguayan Population

Table 2

Coding silent substitutions in the EGFR gene.

	Substitution, coding silent
		COSMIC ID	Nucleotide	Amino acid	rs	Location
1	AA	—	c.2331G>A	p.L777L	—	Chr7: 55.181.340
217	AA = 108	COSM1451600	c.2361G>A	p.Q787Q	rs1050171	Chr7: 55.181.370
	GA = 109
8	TT = 1	COSM85893	c.2508C>T	p.R836R	rs2229066	Chr7: 55.191.757
	CT = 7
1	AA	—	c.2547G>A	p.Q849Q	—	Chr7: 55.191.796
1	TC	—	c.2565 T>C	p.D855D	—	Chr7: 55.191.814

Allele G = 0.405. Hardy-Weinberg Equilibrium value = 0.139. Association test, p.L858R ( value = 0.239) and exon 19 deletions ( value = 0.296).