Effects of Different Treatment Strategies and Tumor Stage on Survival of Patients with Advanced Laryngeal Carcinoma: A 15-Year Cohort Study
Table 2
Crude and adjusted associations between the study variables and laryngeal cancer mortality among patients diagnosed with laryngeal cancer, South of Iran, 2000–2015.
Variable
Univariate
Multivariable
HR
95% CI
P-valu
HR
95% CI
P-valu
Age (year)
<50
-
-
-
-
50–70
2.01
1.22–3.30
0.005
1.83
1.11–3.03
0.017
>70
3.90
2.32–6.55
<0.001
3.76
2.23–6.34
<0.001
Sex
Female
-
-
-
-
Male
1.36
0.50–3.68
0.54
-
-
-
Treatment
RT/CRT
-
-
-
-
Surgery + RT/CRT
0.35
0.24–0.52
<0.001
0.32
0.22–0.47
<0.001
Location
Supraglottic
-
-
-
-
Glottic
1.009
0.70–1.44
0.56
-
-
-
Subglottic
0.85
0.34–2.15
0.74
-
-
-
Transglottic
1.31
0.84–2.04
0.22
-
-
-
Stage
3
-
-
-
-
4
1.72
1.22–2.40
0.002
1.73
1.22–2.45
0.002
T Stage
T3
-
-
-
-
T4
1.63
1.17–2.72
0.004
1.09
0.33–3.63
0.87
Grade
1
-
-
-
-
2
0.92
0.65–1.30
0.65
0.92
0.65–1.31
0.67
3
1.77
1.20–2.63
0.004
1.71
1.14–2.54
0.008
Positive LN
No
-
-
-
-
Yes
1.56
1.12–2.18
0.009
1.59
1.13–2.24
0.008
HR, hazard ratio; CI, confidence interval. category; = not included (remained) in the final model. reported value is for the association of the factor with overall survival; OS, overall survival; RT, radiotherapy; CRT, chemoradiotherapy; CT, chemotherapy; and LN, lymph node.
