Research Article

Influence of Dose Intensity in Consolidation with HIDAC and Other Clinical and Biological Parameters in the Survival of AML

Table 1

Description of the clinical characteristics of patients with AML.

Characteristic (%)

Sex (men)48 (55.8)
Age (years), median (interval)52 (17-82)
 <30 years10 (11.6)
 30–45 years23 (26.7)
 46–60 years21 (24.4)
 >60 years32 (37.2)
Immunophenotype
 Undifferentiated acute myeloblastic (M0)8 (9.3)
 AML with minimal maturation (M1)13 (15.1)
 AML with maturation (M2)13 (15.1)
 Acute myelomonocytic leukemia (M4)4 (4.7)
 Acute monocytic leukemia (M5)21 (24.4)
 AML, not specified (NOS)14 (16.3)
AML and MDS, therapy related
 AML with characteristics of MDS10 (12.0)
 AML secondary to chemotherapy3 (3.5)
Karyotype
 Normal42 (48.8)
 Abnormal25 (29.1)
 No growth7 (8.1)
 Not requested12 (14.0)
Cytogenetic/molecular alterations28 (32.6)
 FLT3 ITD4 (14.2)
 NMP11 (3.6)
 FLT3 ITD with NMP13 (10.7)
 t(9;22)(q34.1;q11.2)1 (3.6)
 Del 5q3 (10.7)
 46 XX -7 +7q- (Del7q)1 (3.6)
 46 XY, right (16)(17)1 (3.6)
 46 XY, -10, +101 (3.6)
 45 XY, t(14p17p), -14,-171 (3.6)
 Trisomy 84 (14.2)
 Trisomy 121 (3.6)
 +6 +8 +121 (3.6)
 46, XY/49, XY, -1, -4, -5, -11, -12, 17, +mar,+mar,+mar,+mar.+mar,+mar,+mar,+mar,+mar1 (3.6)
 Inv (16)1 (3.6)
 t (8;21) (q22;q22.1)4 (14.2)
Cytogenetic risk
 Adverse19 (22.1)
 Intermediate43 (50.0)
 Favorable6 (7.0)
 Undetermined18 (20.9)
WBC count (mm3), median (interval)35090 (500-298400)
Hemoglobin (g/dl), median (interval)8.85 (3.2-16.06)
Platelet count (mm3), median (interval)79460 (2800-570000)