Journal of Chemistry

Journal of Chemistry / 2004 / Article

Open Access

Volume 1 |Article ID 158924 |

Kamal Vashi, H. B. Naik, "Synthesis of Novel Schiff Base and Azetidinone Derivatives and their Antibacterial Activity", Journal of Chemistry, vol. 1, Article ID 158924, 4 pages, 2004.

Synthesis of Novel Schiff Base and Azetidinone Derivatives and their Antibacterial Activity

Received20 Sep 2004
Accepted10 Oct 2004


A series of Compound 4-(2᾽-hydroxy-3᾽-chloro-5᾽-ethyl phen-1᾽-yl)-1-(4᾽-tolyl)-3-chloro-2-azetidinone 4a-j have been prepared by the reaction of 2 -hydroxy-3 -chloro-5 -ethyl-N-(p-tolyl)-chalconimines 3a-j with chloroacetyl chloride in the presence of triethylamine. The Schiff base derivatives 3a-j has been prepared by the condensation of different substituted chalone derivatives 1 with p-toluidine 2. The synthesized compounds were screened for their antibacterial activity against Staphylococcus aureus and Escherichia coli.

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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