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E-Journal of Chemistry
Volume 1 (2004), Issue 5, Pages 228-230
http://dx.doi.org/10.1155/2004/240397

Design, Synthesis and Characterization of Novel Arylamides Containing 1,2,4-triazole Nuclei for Possible Antimicrobial Activity

S. R. Dhol, P. M. Gami, R. C. Khunt, and A. R. Parikh

Chemistry Department, Saurashtra University, Rajkot-360 005, Gujarat, India

Received 18 June 2004; Accepted 10 September 2004

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Diphenyl aceto hydrazide on reaction with carbon disulfide and potassium hydroxide gave potassium α,α-diphenyl acetamido dithiocarbamate, which on cyclisation with hydrazine hydrate yielded key intermediate 3-mercapto-4,N-amino-5-benzhydryl-1,2,4-triazoles. The key intermediate on condensation with different acid chloride afforded our titled compounds. The synthesised compounds have been confirmed elemental analyses and further supported by spectral data. All the synthesised compounds have been evaluated for their in vitroin vitro antimicrobial activity.