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E-Journal of Chemistry
Volume 1 (2004), Issue 4, Pages 189-193

Synthesis of Novel Heterocyclic 4-Thiazolidinone Derivatives and their Antibacterial Activity

K. M. Mistry and K. R. Desai

Department of Chemistry, South Gujarat University, Surat-395 007, India

Received 25 February 2004; Accepted 9 June 2004

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


4-Thiazolidinones have been prepared by the reaction of various substituted Schiff bases 3 with Thioglycolic acid and Thiolactic acid. The intermediate Schiff bases 3 were synthesized by the condensation of various substituted 2-amino benzothiazole 1 with 1-(4'-methyl Phenyl)-3-methyl-5-pyrazolone 2. The starting compound substituted 2-amino benzothiazoles were prepared from various substituted amines via substituted phenyl thiourea. The structures of the compounds have been confirmed by elemental analysis and spectral analysis. The antibacterial activity of the compounds has also been screened against Staphylococcus aureus and Escherichia coli.