Journal of Chemistry

Journal of Chemistry / 2005 / Article

Open Access

Volume 2 |Article ID 237237 |

Jin Tong-Shou, Zhao Ying, Liu Li-Bin, Li Tong-Shuang, "One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Chlorosulfonic Acid", Journal of Chemistry, vol. 2, Article ID 237237, 3 pages, 2005.

One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Chlorosulfonic Acid

Received22 Jul 2005
Accepted28 Aug 2005


An efficient synthesis of 3,4-dihydropyrimidin-2-ones (DHPMs) from the aldehydes, β-ketoesters and urea in ethanol using chlorosulfonic acid as the catalyst is described. Compared with the classical Biginelli reaction conditions, this method has the advantage of excellent yields and short reaction time.

Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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