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E-Journal of Chemistry
Volume 3, Issue 3, Pages 134-136

Derivative Spectrophotometric Estimation of Ondansetron and Paracetamol

P. Ravi Kumar, M. Murali Krishna, P. Bhanu Prakash, B. Anil Kumar, and P. Madhusudhan

Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003. A. P, India

Received 23 February 2006; Accepted 14 April 2006

Copyright © 2006 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A simple and reproducible spectrophotometric method, requiring no prior separation, has been developed for the estimation of ondansetron and paracetamol in combined dosage form. First order derivative spectroscopy method is adopted to eliminate spectral interference. The methods obey Beer’s Law in concentration ranges employed for evaluation. Ondansetron and paracetamol have λmax at 302 nm and 246 nm respectively in methanol. The results of analysis have been validated statistically and recovery studies confirmed the accuracy of the proposed method.