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E-Journal of Chemistry
Volume 3, Issue 3, Pages 142-145
http://dx.doi.org/10.1155/2006/640731

Simultaneous Estimation of Domperidone and Pantoprazole in Solid Dosage Form by UV Spectrophotometry

P. Ravi Kumar, P. Bhanu Prakash, M. Murali Krishna, M. Santha Yadav, and C. Asha Deepthi

Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003, India

Received 23 February 2006; Accepted 14 April 2006

Copyright © 2006 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Domperidone is an antiemetic and pantoprazole is an antiulcer drug. Simple, precise, rapid and selective simultaneous equation and Q- analysis UV spectrophotometric methods have been developed for the simultaneous determination of domperidone and pantoprazole from combined tablet dosage forms. The methods involve solving of simultaneous equations and Q-value analysis based on measurement absorptivity at 216, 287 and 290 nm respectively. Linearity lies between 1-15 mcg/mL for domperidone and 0-50 mcg/mL for pantoprazole.