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E-Journal of Chemistry
Volume 3 (2006), Issue 1, Pages 60-64

RP-HPLC Determination of Raloxifene in Pharmaceuticl Tablets

P. Venkata Reddy, B. Sudha Rani, G. Srinu Babu, and J. V. L. N. Seshagiri Rao

College of Pharmaceutical Sciences, Andhra University., Visakhapatnam-530003, India

Received 1 November 2005; Accepted 23 January 2006

Copyright © 2006 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A reverse phase HPLC method is developed for the determination of Raloxifene in pharmaceutical dosage forms. Chromatography was carried out on an inertsil C18 column using a mixture of acetonitrile and phosphate buffer (30:70 v/v) as the mobile phase at a flow rate of 1 mL/min. Detection was carried out at 290 nm .The retention time of the drug was 10.609 min. The method produced linear responses in the concentration range of 0.5-200 µg/mL of Raloxifene. The method was found to be applicable for determination of the drug in tablets.