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E-Journal of Chemistry
Volume 3, Issue 4, Pages 278-285
http://dx.doi.org/10.1155/2006/765712

Synthesis of Benzimidazole Derivatives: As Anti-hypertensive Agents

Jat Rakesh Kumar,1 Jat Jawahar L.,2 and D. P. Pathak1,2

1Department of Pharmaceutical Science, Guru Jambheshwar University, Hisar-125001, India
2Department of Chemistry, M. L. Sukhadia University, Udaipur (Raj.)-313001., India

Received 11 July 2006; Accepted 22 August 2006

Copyright © 2006 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A new series of non peptide angiotensin(A-II) receptor antagonist has been prepared. This N-(biphenyl methyl) imidazoles e.g. 5-substituted (amino) -2- phenyl-1-(2ʼcarboxy biphenyl-4-yl) benzimidazoles differ from the previously reported and related compounds in that they produce a potent hypertensive effect upon oral administration. The earlier series were generally active only when administered intravenously. It has been found that 2’-position of biphenyl is essential. Only ortho substituted acid possess both high affinity for the AII receptor and oral anti-hypertensive potency.