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E-Journal of Chemistry
Volume 3, Issue 2, Pages 103-109

Synthesis of Novel Azetidinone and Thiazolidinones Derivatives and Evaluation of Their Antimicrobial Efficacy

K. H. Patel and A. G. Mehta

Department of Chemistry, P.T.Science College, Surat, Gujarat, India

Received 26 February 2006; Accepted 14 April 2006

Copyright © 2006 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


2-Amino-4-(2-naphthalenyl) thiazole (1) was prepared from 2-acetylnapthalene. This amine on facile condensation with aromatic aldehydes afford Schiff Base/anils/azomethines(2a-h). These anils on cyclocondensation reaction with chloro acetyl chloride and thio glycolic acid (i.e. mercapto acetic acid) yields 2-azetidinones and 4-thiazolidinones respectively. The prepared compounds have been screened on some stains of bacteria.