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E-Journal of Chemistry
Volume 4, Issue 1, Pages 46-49
http://dx.doi.org/10.1155/2007/454853

Extractive Spectrophotometric Methods for the Determination of Rosuvastatin Calcium in Pure Form and in Pharmaceutical Formulations by Using Safranin O and Methylene blue

Marothu Vamsi Krishna and Dannana Gowri Sankar

Pharmaceutical Analysis and Quality Assurance Division, Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam, India

Received 1 August 2006; Accepted 9 September 2006

Copyright © 2007 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Two simple extractive Spectrophotometric methods are described for the determination of rosuvastatin calcium (RST) in pure form and in pharmaceutical formulations. These methods are based on the formation of ion association complexes of the RST with basic dyes safranin O (Method A) and methylene blue (Method B) in basic buffer of pH 9.8 followed by their extraction in chloroform. The absorbance of the chloroform layer for each method was measured at its appropriate λmax against the reagent blank. These methods have been statistically evaluated and are found to be precise and accurate.