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E-Journal of Chemistry
Volume 4, Issue 1, Pages 50-52
http://dx.doi.org/10.1155/2007/473705

Spectrophotometric Determination of Famciclovir and Racecodotril Using 2, 6-Dichloroquinone–Chlorimide

M. Vamsi Krishna, P. V. Madhavi Latha, and D. Gowri Sankar

Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003., India

Received 2 August 2006; Accepted 8 September 2006

Copyright © 2007 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A simple, sensitive spectrophotometric method for the determination of Famciclovir and Racecodotril is developed. It is based on the formation of a colored oxidative coupling product between 2,6-dichloroquinone-chlorimide and the drug is described. The method has been extended to pharmaceutical preparations. The absorption maxima and Beer’s law limits for Famciclovir are 500 nm, 20-100 µg/mL and for Racecodotril are 460 nm, 12.5-62.5 µg/mL.