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E-Journal of Chemistry
Volume 4, Issue 1, Pages 79-82
http://dx.doi.org/10.1155/2007/480625

Spectrophotometric Determination of Raloxifene Hydrochloride in Pharmaceutical Formulations

M. Mathrusri Annapurna, M. E. Bhanoji Rao, and B. V. V. Ravi Kumar

Department of Pharmaceutical Chemistry, Roland Institute of Pharmaceutical Sciences, Ambapua, Berhampur, Orissa-760010, India

Received 6 September 2006; Accepted 15 October 2006

Copyright © 2007 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Three new simple, sensitive, rapid and economical spectrophotometric Methods (A, B and C) have been developed for the determination of Raloxifene Hydrochloride in pharmaceutical bulk and tablet dosage form. Method A is based on the formation of yellow colored chromogen with 0.1N Sodium hydroxide exhibiting maximum absorbance against the corresponding reagent blank. The method B is based on the reaction of Raloxifene with Ferric chloride and 1, 10-phenanthroline to form blood red colored chromogen. The method C is based on the formation of blood red colored chromogen with Ferric chloride and 2, 2' bipyridyl. The absorbencies of the chromogens were measured at their respective wavelength of maximum absorbance against the corresponding reagent blank. The proposed methods have been successfully applied to the analysis of the bulk drug and its tablet dosage form. The methods have been statistically evaluated and were found to be precise and accurate.