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E-Journal of Chemistry
Volume 4 (2007), Issue 2, Pages 216-221
http://dx.doi.org/10.1155/2007/915470

Simple and Rapid Methods for the Analysis of Captopril in Dosage Forms

H. Chandru1 and A. C. Sharada2

1Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysore-57006, Karnataka, India
2Department of Biochemistry, Yuvaraja’s College University of Mysore, Mysore-570005, Karnataka, India

Received 16 October 2006; Revised 7 December 2006; Accepted 24 December 2006

Copyright © 2007 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Two indirect methods are described for the micro determination of captopril using hexacyanoferrate (III) as reagent. The reaction used for titrimetry proceeds at room temperature and will be complete in 10 minute with a stoichiometry of 1:1 with respect to the oxidant and captopril. The reaction product used for spectrophotometric determination shows the absorption maximum at 510 nm. The Beer’s law is obeyed over the concentration range 0.25-12.00 μg mL-1, the molar absorptivity and Sandell sensitivity for the system being 9.14×103 L mol-1cm-1 and 23.78 ng cm-2, respectively. The limit of detection and quantification are found to be 0.08 and 0.26 μg mL-1, respectively. Both procedures have been applied to the determination of captopril in tablets. The results have been statistically compared with those obtained by the official (BP) method.