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E-Journal of Chemistry
Volume 5 (2008), Issue 4, Pages 688-695

An Efficient and Recycling Catalyst for the One-Pot Three-Component Synthesis of Substituted 3,4-Dihydropyrimidin-2(1H)-ones

Taoues Boumoud,1 Boudjemaa Boumoud,1 Salah Rhouati,1 Ali Belfaitah,1 Abdelmadjid Debache,1 and Paul Mosset1,2

1Laboratoire des Produits Naturels d’origine Végétale et de Synthèse Organique. Département de Chimie. Faculté des Sciences. Universit Mentouri de Constantine 25000 Constantine, Algeria
2Sciences Chimiques de Rennes, CNRS UMR 6226, ENSCR, Avenue du Leclerc, 35700 Rennes, France

Received 3 December 2007; Accepted 1 February 2008

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The Biginelli one-pot three-component cyclocondensation was applied in this work to prepare 3,4-dihydropyrimidinone and its analogues using the first derivative of lead, Pb(NO3)2, as a recycling catalyst, from a diversity of aromatic aldehydes, β-ketoesters and urea. The reaction was carried out in refluxing acetonitrile and afforded the target molecules in good to excellent yields. The method offers several advantages including high yields of the products, short reaction times and easy experimental workup procedure