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E-Journal of Chemistry
Volume 5 (2008), S1, Pages S1008-S1014
http://dx.doi.org/10.1155/2008/249245

Synthesis and Study of Some Newer Analogues ofQuinolin-8-ol as Potent Antimicrobial Agents

Jyoti Sharma,1 Sabir Hussain,1 and Mohammad Amir2

1Department of Chemistry, R. R. College, Alwar, Rajasthan, India
2Department of Pharmaceutical Chemistry, Jamia Hamdard, New Delhi, India

Received 22 May 2008; Revised 19 June 2008; Accepted 23 June 2008

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

New series of 4-(substituted phenyl)-5-[(quinolin-8-yloxy) methyl]-4H-1,2,4-triazole-3-thiol (4a-c), N³-(4-substituted phenyl)-5-[(quinolin-8-yloxy) methyl]-4H-1,2,4-triazole-3,4-diamine (5a-c) and N-(4-substituted phenyl)-5-[(quinolin-8-yloxy) methyl]-1,3,4-thiadiazol-2-amine (6a-g) have been synthesized and the structures of the new compounds were established on the basis of IR, 1H NMR spectral data. In vitro antimicrobial activity (MIC activity) was evaluated and compared with standard drugs of loxacin and ketoconazole. Compounds 5a and 6e in the series have shown interesting antibacterial activity against both S. aureus (gram-positive) and E. coli (gram-negative) organisms. In this paper, we also describe studies leading to identification of antifungal agents. In the gratifying result, most of the compounds were found to have moderate antimicrobial activity.