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E-Journal of Chemistry
Volume 5 (2008), Issue 1, Pages 120-129

Microwave Assisted Improved Method for the Synthesis of Pyrazole Containing 2,4,-Disubstituted Oxazole-5-one and their Antimicrobial Activity

N. D. Argade,1 B. K. Kalrale,1 and C. H. Gill2

1P. G. Department of Chemistry, S.S.G.M. Collage, Kopergone, Ahmednagar-423601 (MS), University of Pune, India
2Department of Chemistry, Dr.B.A.Marathwada University, Aurangabad-431004 (MS), India

Received 5 June 2007; Accepted 20 July 2007

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Disubstituted oxazol-5-one and pyrazoles are known to exhibit various biological activities. Therefore, in this work, we designed pyrazole containing 2,4-disubstituted oxazol-5-one (3a-g) as a new class of antimicrobial agents. Synthesis of titled compounds was carried out by two different methods. In the first method (conventional Method A), disubstituted oxazol-5-one (3a-g) was prepared by reacting 1-phenyl-3-p-tolyl-1H-pyrazole-4-carbaldehyde (1a-g) with hippuric acid (2) and sodium acetate, in an acetic anhydride for 2.5 - 4 h. In the second method (Method B), the above reaction was carried out under microwave assistance. Compared to the conventional method, the microwave-assisted synthesis of 3,4,5-trisubstituted imidazoles demonstrate several advantages, in terms of reaction time and overall yield. All the test compounds were evaluated for in vitro antibacterial and antifungal activities. In general, compounds with electron withdrawing groups showed good antibacterial and antifungal activities. Among the compound tested, compound (3d) showed highest activity.