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E-Journal of Chemistry
Volume 5 (2008), Issue 3, Pages 562-566

Isolation, Synthesis and Characterization of Rosiglitazone Maleate Impurities

Singamsetty Radha Krishna,1 Mandava Venkata Naga Brahmeshwar Rao,1 Tirmalaraju Satyanaryana Raju,1 Vurimidi Himabindu,2 and Ghanta Mahesh Reddy1

1Research and Development, Dr. Reddy's Laboratories Ltd., Integrated Product and Development, Unit-III, Plot No. 116, S V Co-Op. Ind. Estate, Bollaram, Jinnaram, Medak Dist 502 325; A P, India
2Institute of Sciences and Technology, Center for Environmental Sciences, J.N.T. University, Kukatpally, Hyderabad-500072, India

Received 15 November 2007; Accepted 2 January 2008

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Three unknown impurities in rosiglitazone maleate 1 bulk drug at level below 0.1% (ranging from 0.05 to 0.1%) were detected by simple reverse phase high performance liquid chromatography. These impurities were preliminarily identified with LC-MS and characterized by the mass number of the impurities. Different experiments were conducted and finally synthesized and characterized the unknown impurities.