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E-Journal of Chemistry
Volume 5 (2008), Issue 1, Pages 23-33

Synthesis and Antimicrobial Activity of Some Novel Substituted Piperazinyl-quinazolin-3(4H)-ones

N. M. Raghavendra, P. P. Thampi, and P. M. Gurubasavarajaswamy

Medicinal Chemistry Research Laboratory, Acharya and B.M. Reddy College of Pharmacy, Bangalore, Karnataka, India

Received 26 July 2007; Accepted 20 September 2007

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Several substituted-quinazolin-3(4H)-ones were synthesized by condensation of 2-chloro-N-(4-oxo-substituted-quinazolin-3(4H)-yl)-acetamides with various substituted piperazines through single step reaction. Elemental analysis, IR, 1HNMR and mass spectral data confirmed the structure of the newly synthesized compounds. Synthesized quinazolin-4-one derivatives were investigated for their antibacterial and antifungal activities.