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E-Journal of Chemistry
Volume 5 (2008), Issue 1, Pages 144-148

Synthesis and Antimicrobial Activity of Some New Chalcones of 2-Acetyl Pyridine

Y. Rajendra Prasad, P. Praveen Kumar, P. Ravi Kumar, and A. Srinivasa Rao

University College of Pharmaceutical Sciences, AndhraUniversity, Visakhapatnam-530 003, (A.P), India

Received 17 July 2007; Accepted 20 September 2007

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Six new chalcones were synthesised by condensing 2-acetyl pyridine with aldehyde derivatives in dilute ethanolic potassium hydroxide solution at room temperature according to Claisen-Schmidt condensation. All these compounds were characterised by means of their IR, 1H NMR spectroscopic data and microanalyses. The antimicrobial activity of these compounds was evaluated by the cup plate method.