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E-Journal of Chemistry
Volume 5, Issue 2, Pages 370-376
http://dx.doi.org/10.1155/2008/659752

Synthesis and Antimicrobial Studies of a New Series of Bis-Heterocycles

B. Jayashankara and K.M. Lokanatha Rai

Department of Studies in Chemistry, University of Mysore, Manasagangothri, Mysore-570006, India

Received 7 September 2007; Accepted 14 November 2007

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Series of novel bis-heterocycles bearing isoxazoline and imidazole moieties have been synthesized via 1,3-dipolarcycloaddition reactions. 1HNMR, 13CNMR, IR and elemental analyses characterized the newly synthesized compounds. All the synthesized compounds were evaluated for their antimicrobial activity and were compared with the standard drugs. The compounds demonstrated potent to weak antimicrobial activity.