Journal of Chemistry

Journal of Chemistry / 2008 / Article

Open Access

Volume 5 |Article ID 853596 | https://doi.org/10.1155/2008/853596

Marothu Vamsi Krishna, Dannana Gowri Sankar, "Simple Spectrophotometric Determination of Torsemide in Bulk Drug and in Formulations", Journal of Chemistry, vol. 5, Article ID 853596, 6 pages, 2008. https://doi.org/10.1155/2008/853596

Simple Spectrophotometric Determination of Torsemide in Bulk Drug and in Formulations

Received07 Apr 2007
Accepted12 Jun 2007

Abstract

A simple and cost effective spectrophotometric method is described for the determination of torsemide in pure form and in pharmaceutical formulations. The method is based on the formation of blue colored chromogen when the drug reacts with Folin-Ciocalteu (F-C) reagent in alkaline medium. The colored species has an absorption maximum at 760 nm and obeys beer's law in the concentration range 30 – 150 ug mL−1. The absorbance was found to increase linearly with increasing concentration of TSM, which is corroborated by the calculated correlation coefficient value of 0.9999 (n=8). The apparent molar absorptivity and sandell sensitivity were 1.896×103 L mol−1 cm−1 and 0.183 μg cm−2, respectively. The slope and intercept of the equation of the regression line are 5.4x10−3 and 1.00×10−4 respectively. The limit of detection was 0.94.The optimum experimental parameters for the reaction have been studied. The validity of the described procedure was assessed. Statistical analysis of the results has been carried out revealing high accuracy and good precision. The proposed method was successfully applied to the determination of TSM in pharmaceutical formulations.

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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