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E-Journal of Chemistry
Volume 5 (2008), Issue 3, Pages 567-571

Synthesis of Benzofuro[3,2-e]-1,4-diazepines of Pharmacological Interest

K. M. Basavaraja,1 V. P. Vaidya,2 and C. Chandrashekhar2

1Department of Industrial Chemistry, Gulberga University, Jnana Ganga, Bellary-Dist: Bellary, Karnataka, India
2Department of Chemistry, Kuvempu University, Jnana Sahyadri, Shankaraghatta-577451 Dist: Shimoga, Karnataka, India

Received 16 October 2007; Accepted 2 January 2008

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The title compounds (4a,b) were prepared by chloroacetylation of 2-acyl-3-aminobenzofuran(1a,b) and subsequent treatment with hexamethylene tetramine in ethanol via the complex salts (3a,b). Similar reaction with ethyl 3-aminobenzofuran-2 carboxylate (5) produced 3H-benzofuro[3,2-e]-1,4-diazepin2,5(1H,4H)-dione (7) in good yield. All the newly synthesized compounds are characterized by elemental analysis and spectral studies, and evaluated for antimicrobial and anticonvulsant activities.