Journal of Chemistry

Journal of Chemistry / 2008 / Article

Open Access

Volume 5 |Article ID 945140 |

Afaf Abul Khier, Magda M. Elhenawee, Manal S. Elmasry, "Spectrophotometric Method for the Determination of Some Drugs Using Fast Red B Salt", Journal of Chemistry, vol. 5, Article ID 945140, 11 pages, 2008.

Spectrophotometric Method for the Determination of Some Drugs Using Fast Red B Salt

Received15 Dec 2007
Accepted10 Feb 2008


A simple spectrophorometric method for the determination of secnidazole, niclosamide, nifuroxazide and sulphasalzine is described. The method is based on reduction of the nitro group present in secnidazole and niclosamide molecule using zinc powder and dilute hydrochloric acid followed by reaction with fast red B salt in presence of ammonium chloride and sodium hydroxide, while in case of nifuroxazide and sulphasalazine the reaction takes place directly without any prior reduction between the phenolic group present in each drug and fast red B salt in presence of sodium hydroxide. Beer's law is valid in the concentration ranges 2.5-15, 1.25-10, 2.5-15, and 2.5-13.75 μg.mL-1 for secnidazole, niclosamide, nifuroxazide and sulphasalazine respectively. The proposed method is applied successfully for the estimation of the mentioned drugs either in pure form or in their pharmaceutical formulations.

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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