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E-Journal of Chemistry
Volume 6 (2009), S1, Pages S123-S128

Synthesis and Anti-inflammatory Activity of Some Novel Pyrazole Derivatives of Gallic Acid

S. Arunkumar,1 K. Ilango,1 R. S. Manikandan,1 and N. Ramalakshmi2

1Department of Pharmaceutical Chemistry, S.R.M. College of Pharmacy, S.R.M University, Kattankulathur-603203, Tamilnadu, India
2Department of Pharmaceutical Chemistry, C.L. Baid Metha College of Pharmacy, Thoraipakkam, Chennai-600096, Tamilnadu, India

Received 12 March 2009; Accepted 22 April 2009

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In the present study, a new series of [5-substituted-3-(phenylamino)-1H-pyrazol-1yl] (3,4,5-trihydroxyphenyl)-methanone (4a-j) have been synthesized. 3, 4, 5-Trihydroxy benzohydrazide (1) was synthesized from propyl gallate and hydrazine hydrate in presence of ethanol. Chalcones (2a-j) were synthesized from acetanilide and various aromatic aldehydes in presence of ethanol and sodium hydroxide solution. By refluxing the compound (1) and compounds (2a-j) in presence of ethanol yielded [5-substituted-3-(phenylamino)-4.5-dihydropyrazol-1yl] (3,4,5-trihydroxy phenyl)-methanone (3a-j). The final compounds [5-substituted-3-(phenylamino)-1H-pyrazol-1yl] (3,4,5-trihydroxyphenyl)-methanone (4a-j) were synthesized by treating compounds (3a-j) with bromine water. The synthesized compounds have been characterized by IR, 1HNMR and Mass spectral data. The compounds were evaluated for in vivo anti-inflammatory activity by carrageenan induced paw edema test. In general all compounds were found to exhibit good anti-inflammatory activity.