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E-Journal of Chemistry
Volume 6 (2009), Issue 2, Pages 553-560
http://dx.doi.org/10.1155/2009/190346

Phytochemical Composition and Biological Activities of Uvaria chamae and Clerodendoron splendens

Donatus Ebere Okwu and Friday Iroabuchi

Department of Chemistry, Michael Okpara University of Agriculture, Umudike, PMB 7267, Umuahia, Abia State, Nigeria

Received 29 June 2008; Accepted 1 September 2008

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Uvaria chamae P. Beauv and Clerodendron splendens A Cheval are known to have various medicinal and therapeutic properties. Their anti-inflammatory and oxytocic properties were assessed in this study. The extracts and aspirin were found to inhibit carrageenan-induced paw oedema on albino rats and mice with a strong activity in aspirin having (80.43 %) inhibition while U. chamae and C. splendens have 69.57% and 47.83% inhibition respectively. The plants extract exhibition and uterine contraction activity on guinea pig. Phytochemical studies on the plants revealed the presence of bioactive components comprising flavonoids (0.70 – 5.70 mg. 100 g-1), alkaloids (0.81-5.40 mg. 100 g-1), tannins (0.40 – 3.60 mg. 100 g-1), saponins (0.38 – 2.10 mg. 100 g-1) and phenols (0.08 – 0.10 mg. 100 g-1). These bioactive compounds may be responsible for the medicinal properties of U. chaemae and C. splendens that form the basis of their use in herbal medicine in Nigeria.