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E-Journal of Chemistry
Volume 6, Issue 1, Pages 207-212
http://dx.doi.org/10.1155/2009/280961

Extractive Spectrophotometric Methods for the Determination of Etoricoxib in Tablets

Kamal Shah,3 Alka Gupta,2 and Pradeep Mishra1

1Dr. Hari Singh Gour University, Sagar, (M.P.), India
2IPS College of Pharmacy, Gwalior, (M.P.), India
3GLA, Institute of Pharmaceutical Research, Mathura (U.P.), India

Received 3 June 2008; Accepted 1 August 2008

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Two simple, rapid, sensitive, precise and economic spectrophotometric methods have been developed for the estimation of etoricoxib in tablet formulation. During the course of study, it was observed that acidic solution of the drug formed colored ion-association complexes with Bromocresol Green (BCG) and Bromocresol Purple (BCP) which were soluble in chloroform. This property of the drug was followed for the development of colorimetric methods for analysis of drug. The complex of etoricoxib with BCG and BCP showed λmax at 416 nm and 408 nm respectively. These methods were validated statistically. Recovery studies gave satisfactory results indicating that none of common additives and excipients interfere the assay method. The proposed methods are found to be simple, accurate and reproducible that was successfully applied for the analysis of tablet formulation.