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E-Journal of Chemistry
Volume 6 (2009), S1, Pages S406-S412

Studies on Novel N4-[4,6-Diaryl-2-pyrimidinyl]-7-chloro-4-quinolinamine and their Microbicidal Efficacy

Arvind G. Mehta and Avnish A. Patel

Department of Chemistry, Sir P. T. Sarvajanik College of Science, Veer Narmad South Gujarat University, Surat-395017, Gujarat, India

Received 11 June 2009; Accepted 18 July 2009

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The required chalcones 1a-h were prepared by reaction of substituted acetophenone with different aryl aldehyde, which in turn treated with guanidine nitrate, yielded 4-(substituted phenyl)-6-(substituted phenyl)-2-pyrimidinamine 2a-h. Novel pyrimidine quinoline clubbed molecules 3a-h have been prepared by reaction of 2a-h with 4,7-dichloroquinoline. All the compounds were characterized by elemental analysis and spectral studies. The newly synthesized compounds were evaluated for their antibacterial and antifungal activity.