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P2O5/SiO2 as an Efficient, Green and Heterogeneous Catalytic System for the Solvent-Free Synthesis of 3,4-Dihydropyrimidin-2-(1H)-ones (and -Thiones)
Alireza Hasaninejad
,1 Abdolkarim Zare,2 Farhad Jafari,2 and Ahmad Reza Moosavi-Zare21Department of Chemistry, Faculty of Sciences, Persian Gulf University, Bushehr 75169, Iran
2Department of Chemistry, College of Sciences, Payame Noor University (PNU), Bushehr 1698, Iran
Abstract
A simple, green and efficient solventless procedure for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones (and -thiones) from aldehydes, β-ketoesters and urea or thiourea in the presence of catalytic amount of silica-supported P2O5 (P2O5/SiO2) at 85 °C is described. Using this method, the title compounds were produced in high yields.
Copyright
Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
