Journal of Chemistry

Journal of Chemistry / 2009 / Article

Open Access

Volume 6 |Article ID 303781 | 7 pages |

P2O5/SiO2 as an Efficient, Green and Heterogeneous Catalytic System for the Solvent-Free Synthesis of 3,4-Dihydropyrimidin-2-(1H)-ones (and -Thiones)

Received27 Jul 2008
Accepted09 Sep 2008


A simple, green and efficient solventless procedure for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones (and -thiones) from aldehydes, β-ketoesters and urea or thiourea in the presence of catalytic amount of silica-supported P2O5 (P2O5/SiO2) at 85 °C is described. Using this method, the title compounds were produced in high yields.

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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